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Now showing items 21180-21199 of 41823
Immunotherapy of chronic virus infections : Exhausted CD8+ T cell subsets are differentially regulated by XCR1 + DC
The contribution of cross-presenting XCR1+ dendritic cells (DC) in maintaining T cell function during exhaustion and immuno-therapeutic interventions of chronic infections remains poorly characterized. Using the mouse model ...
Immunotherapy with memory “stem” Tcells modified with chimeric antigenspecific receptors (CARs) for patients with lymphoid neoplasms
La teràpia cel·lular adoptiva amb cèl·lules T modificades amb un receptor quimèric antigen-específic (CAR) dirigit contra CD19 ha demostrat resultats excel·lents en les neoplàsies de cèl·lules B. No obstant això, la seva ...
Impact assessment of the façades' actual state on the energy performance gap of residential buildings
Bridging the gap between the predicted and actual energy performance of buildings is necessary to increase the energy performance of existing buildings and achieve the European Union’s energy efficiency targets in the “2030 ...
Impact hazard associated with large meteoroids from disrupted asteroids and comets
El impacto de grandes fragmentos desprendidos de cometas y asteroides contra la Tierra puede llegar a ser muy peligroso. Recientemente, sucesos como Chelyabinsk (2013), Carancas (2007) o Tunguska (1908) han demostrado la ...
Impact of a SIGLEC1 null variant on the pathogenesis of HIV-1 and Mtb infection
Les cèl·lules presentadores d’antigen de llinatge mieloide tenen la capacitat de respondre a una infecció d’una manera ràpida i eficient coordinant respostes immunitàries innates i adaptatives. Malgrat això, en el cas de ...
Impact of adipose tissue on endothelial cells: effect of metabolic disorders
This thesis aims to progress in deciphering the effect of the cytokines secreted by the visceral adipose tissue of obese individuals with type 2 diabetes on the endothelium, and therefore contribute to the understanding ...
Impact of adult students' time perspective on time-on-task and learning performance using game based learning
The use of game-based learning (GBL) methodologies is increasing in online higher education in general, and in business education in particular, despite the small amount of research that exists on the effectiveness of these ...
Impact of Alzheimer's disease risk factors on white matter hyperintensities and cognition in cognitively unimpaired individuals
White matter hyperintensities (WMH) have been associated with increased risk and progression of Alzheimer’s disease (AD). However, the range to which this association can be extended to AD risk factors and WMH burden in ...
Impact of cancer cell plasticity on tumor immune microenvironment and immunotherapy response
[spa] La mayoría de los carcinomas escamosos de piel (cSCCs) se tratan con éxito mediante escisión quirúrgica. Sin embargo, el 5-8% de los casos desarrollan recurrencias, las cuales están asociadas a un crecimiento ...
IMPACT OF CHANNEL STATE INFORMATION ON THE ANALYSIS AND DESIGN OF MULTIANTENNA COMMUNICATION SYSTEMS
Al llarg d'aquesta última dècada, s'ha produit un creixement constant en la demanda d'elevades taxes de transmissió de dades que han de suportar les aplicacions sobre comunicacions sense fils. Entre les diferents solucions ...
Impact of Childhood Trauma on Levels of Depressive Symptoms, Pain, Functionality, and Cognitive Conflicts in Fibromyalgia
[eng] In recent years, much scientific evidence has shown the role of child maltreatment in human development, which impacts all aspects of growth, physical, behavioral, emotional, and cognitive. Depending on the extent ...
Impact of chlorophenols and heavy metals on soil microbiota: their effects on activity and community composition, and resistant strains with potential for bioremediation
Pollution by toxic compounds is one of the most relevant environmental damages to ecosystems produced by human activity and, therefore, it must be considered in environmental protection and restoration of contaminated ...
The impact of chromosome positioning in nuclear functions
Chromatin is not randomly organized inside the eukaryotic nucleus in interphase. In budding yeast gene expression of some specific loci is affected by their positioning in the nucleus. Replication firing of early origins ...
Impact of drought periods on carbon processing across surface-hyporheic interfaces in fluvial systems = Impacte dels períodes de sequera sobre el processat de carboni a través de la interfase superficial i zona hiporreica en sistemes fluvials
Headwater streams essentially link the terrestrial and the aquatic carbon cycle because they transport terrestrial organic and inorganic carbon downstream towards the oceans. However, most of these inputs are processed ...
Impact of Emotional Intelligence, Leadership Traits and Culture on Leadership Style in Hospitality: Propensity of Green Management Practices Implementation
[eng] The PhD dissertation aims to investigate the impact of emotional intelligence, leadership traits and culture on leadership style in hospitality and the propensity of green management practices implementation. The ...
Impact of energy metabolism, paraoxonase-1, and inflammation on cancer patient's prognosis and response to treatment
El càncer és una preocupació sanitària mundial i un gran repte per augmentar l'esperança i la qualitat de vida dels pacients. Considerant que el metabolisme relacionat amb el balanç energètic, l'estrès oxidatiu i la ...
Impact of fatty acid metabolism in breast cancer peritumoral tissue. Clinical and pathogenic aspects
El càncer de pit es el càncer més comú en dones i el segon càncer amb més morts relacionades. Conèixer el comportment de les cèl·lules tumorals en el seu microambient pot obrir noves posibilitats d’estudis i dianes ...
Impact of feedback in students' engagement: The case of MOOCs
Our results provided insights, first of all, on how student engagement can be measured in MOOCs and also which feedback factors affect student engagement, for instance: the existence and type of assessment; the actors ...
Impact of game restocking on common quail populations
The common quail (Coturnix coturnix) is a popular game bird in Europe. The massive restocking of farm-reared individuals for hunting purposes is a common practice in several European countries. Although restocking of common ...
Impact of gene-environment interaction on the real-world expression of psychosis risk: linking genetic variation, childhood adversity and daily-life experiences across the extended psychosis phenotype
La investigación en el ámbito de la interacción gen-ambiente, basada en la sinergia de factores genéticos y ambientales, ha tenido una gran relevancia en el campo de la psicosis. El principal objetivo de la tesis fue ...
