Universitat Pompeu Fabra
Now showing items 1-19 of 19
A multiple sequence alignment (MSA) provides a description of the relationship between biological sequences where columns represent a shared ancestry through an implied set of evolutionary events. The majority of research ...
Current biomedical research needs to leverage the large amount of information reported in scientific publications. Automated text processing, commonly known as text mining, has become an indispensable tool to identify, ...
New high-throughput behavioral systems enable the recording of continuous behavioral sequences with an unprecedented richness of signals and a deep temporal resolution. Automated systems offer neuroscience the opportunity ...
The work on this thesis has focused on the development of integrated databases and visualization tools for three related areas of biomedical sciences involved in the drug discovery process. An annotated chemical library ...
Appropriate regulation of gene expression is necessary for correct development and homeostasis of organisms. Epigenetic mechanisms represent an additional layer of information, besides the genetic sequence, crucial for the ...
La consonancia es una de las características más salientes de la música. A pesar de su papel fundamental en la música occidental, sus orígenes siguen siendo controversiales. Por lo tanto, la comprensión de los mecanismos ...
Synthetic biology is a fairly recent field that aims to engineer novel functions in biological systems. In a broad sense synthetic biology encompasses the development of tools that makes the engineering of biology easier. ...
Biological systems gather information from the environment and perform computations at multiple levels. Advancements in molecular biology and techniques for cell manipulation, genome engineering and DNA synthesis among ...
Living beings strive to survive and reproduce. To do so they need to monitor and adapt to a dynamic environment, taking advantage of the opportunities and dodging the threats that they may encounter. This thesis is devoted ...
Synthetic Biology is a relatively new and multi-faceted interdisciplinary emergent field of research that combines biology with technology in novel and exciting ways. One of its main branches aims to see living systems ...
Las membranas celulares contienen un canal de Cl- (Maxi-Cl-) que es modulado por estrógenos y antiestrógenos. El trabajo experimental de mi tesis doctoral ha consistido en el estudio de la modulación de este canal y su ...
Organisms need to integrate its previous experience with its current internal state in order to deliver a suitable response to dynamic changes in their environment. This thesis is devoted to analyze, using a mathematical ...
Las enfermedades y otros procesos biológicos son complejos y están producidos por la interacción de múltiples factores genéticos y ambientales. En las últimas décadas, los métodos tradicionales reduccionistas han dado paso ...
Despite some great success, many human diseases cannot be effectively treated, prevented or cured, yet. Moreover, prescribed drugs are often not very efficient and cause undesired side effects. Hence, there is a need to ...
This thesis tackles a series of phenomena across diverse fields from the point of view of optimization. The problems studied often bring together diverse conflicting constraints that cannot be fully satisfied. Out of ...
Numerous studies have shown that a wide range of behaviors from sensory processing to motor control involve near-optimal probabilistic inference. Most of these studies have focused on vertebrates, suggesting that the ability ...
The breakthrough in the technological field has allowed the extraction of large amounts of the so-called omics data. The analysis and Integration of this type of data by means of advanced statistical and bioinformatics ...
One of the branches of synthetic biology pursues the creation of a biological computer. Many have successfully implemented simple logic circuits rewiring cellular components. However, these circuits may aggressively compete ...
The purpose of my doctoral studies was to develop an algorithm for large-scale analysis of protein sets. This thesis outlines the methodology and technical work performed as well as relevant biological cases involved in ...
