Facultat de Biologia: Recent submissions
Now showing items 141-160 of 236
Compound F: A novel nuclear receptor modulator and its potential application on hematologic malignancies
Compound F has been reported to possess important antioxidant, anti-inflammatory, anti- diabetic and anti-cancer effects, among other interesting properties. Although Compound F has been extensively investigated, its ...
Noves aproximacions terapèutiques en la Distrofia Muscular de Duchenne i validació d'estratègies diagnòstiques en les malalties neuromusculars pediàtriques
Els trastorns neuromusculars pediàtrics són malalties minoritàries causades per un gran nombre de gens, molts d’ells de gran mida i d’estructura complexa, fet que dificulta enormement el diagnòstic molecular i el disseny ...
Application of chemotaxonomy to the study of the phytoplankton community structure in the Mediterranean Sea and in the Atlantic and Southern Oceans = Aplicación de la quimiotaxonomía al estudio de la estructura de la comunidad fitoplanctónica en el Mar Mediterráneo y en los oceános Atlántico y Antártico
Despite their small size, phytoplankton represents up to 50% of the global primary production of the Earth and serves as a connector between oceanic and atmospheric processes. Therefore, phytoplankton constitutes a central ...
Identificación y caracterización de alteraciones epigenéticas responsables de síndrome de Lynch y Lynch-like
La deficiencia reparadora es una característica de los tumores de individuos con síndrome de Lynch, los cuales son portadores de mutaciones o epimutaciones en línea germinal de los genes reparadores de desapareamientos del ...
Improving the description of protein-protein association energy
Proteins play a crucial role in virtually every biological process taking place within our cells. Most of the times, proteins do not participate in these processes alone but forming complexes of two or more proteins. ...
Bases genètiques del trastorn per dèficit d'atenció amb hiperactivitat i de la resposta farmacològica al metilfenidat
El trastorn per dèficit d’atenció amb hiperactivitat (TDAH) és un trastorn del neurodesenvolupament caracteritzat per símptomes d’inatenció i/o hiperactivitat/impulsivitat. Nombrosos estudis suggereixen un important component ...
ROV-based ecological study and management proposals for the offshore marine protected area of Cap de Creus (NW Mediterranean)
Aiming to improve the conservation status of the European seas, the Marine Strategy Framework Directive (MSFD) was adopted in 2008, establishing a general framework for all EU countries in the field of marine environmental ...
Patterns of genetic and morphologic diversity in Antarctic sponges = Modelos de diversidad genética y morfológicas en las esponjas antárcticas
The Antarctic bottoms harbour rich communities of sponges, which play an important role in structuring benthic habitats. Many Antarctic sponge species have been discovered in the past but most of them were poorly described ...
Fish and mammalian glut4 traffic characteristics: an evolutionary perspective on the importance of glut4 protein motifs for trafficking
Glucose transporters (GLUTs) are extremely important for glucose metabolism. Glucose transporters uptake glucose from blood stream into the cells where it can be metabolized. Among the glucose transporters family, GLUT4, ...
Morfología del sistema digestivo y larvicultura del centollo (Maja brachydactyla, Balss 1922)
La presente Tesis Doctoral está centrada en el centollo atlántico (Maja brachydactyla Balss, 1922). Los objetivos incluyen la optimización del cultivo larvario y el estudio ontogénico del sistema digestivo. El cultivo ...
Demographics and population ecology of the range-expanding zooxanthellate coral Oculina patagonica in the Mediterranean Sea
Shallow-water rocky ecosystems in temperate areas are dominated by macroalgae, whilst zooxanthellate corals are extremely rare. In an era of global change, sea warming plays a crucial role in the widespread phase shifts ...
Role of MAF in bone metastasis
The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them preventive treatments. ...
Role of p38α in lung tumor progression
Tumors evolve by sequentially acquiring genetic abnormalities, like K-Ras activation and Tp53 loss of function, which enable transformed cells to survive, proliferate, invade, and reprogram their microenvironment. ...
Towards biological and ecological knowledge of Lophius spp. in the NW Mediterranean Sea for a sustainable fishery
In the northwestern Mediterranean Sea, anglerfishes Lophius budegassa Spinola, 1807 and Lophius piscatorius Linnaeus, 1758 are among the most valuable demersal species and support an important fishery. Both anglerfishes ...
Desarrollo de un sistema para el control de la plausibilidad relacionado con las magnitudes hematológicas
INTRODUCCIÓN: En el laboratorio clínico, antes de entregar el informe al solicitante, se realiza una revisión final de los resultados con la finalidad de detectar la existencia de resultados sospechosos de contener errores ...
Uncivering mechanisms of acquired resistance to trastuzumab-emtansine (T-DM1) in HER2 positive breast cancer
Trastuzumab-emtansine (T-DM1) is an antibody-cytotoxic agent (DM1) conjugated drug. DM1 delivery by trastuzumab inside the HER2 positive cells affects microtubule polymerization, cell cycle arrest and finally cell death. ...
Ecology and biodiversity of the deep-sea meiobenthos from the Blanes Canyon and its adjacent slope (NW Mediterranean) = Ecología y biodiversidad del meiobentos profundo del Cañón de Blanes y su talud adyacente (NO Mediterráneo)
Submarine canyons are major topographic structures forming deep incisions in shelfs and continental margins around the globe. Due to their topographic characteristics, canyons influence both local hydrodynamic conditions ...
Uso de líneas celulares como modelos in vitro para la evaluación de toxicidad y mecanismos de acción de contaminantes ambientales
En esta tesis se investiga la utilidad de diferentes bioensayos basados en el uso de líneas celulares (peces/humanas) y fracciones subcelulares, para la caracterización del riesgo ambiental que diversos contaminantes ...
EPHA2 com a diana terapèutica pel sarcoma d'Ewing
El sarcoma d’Ewing (SE) és el segon tumor ossi més freqüent en nens i adults joves, i presenta una incidència d’un màxim de 5 casos per milió en adolescents. Una de les característiques principals del SE és la seva gran ...
Growth and dynamics of Hemimycale columella (Demospongiae, Poecilosclerida) and the relationship with its microbial symbionts = Crecimiento y dinámica de Hemimycale columella (Demospongiae, Poecilosclerida) y la relación con sus simbiontes microbianos
El estudio se centra la filogenia, biología y ecología de la demosponja Hemimycale columella y su simbiosis con una bacteria calcificadora (calcibacteria). Posteriormente se incorporaron otras especies para entender tanto ...
